Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 703555..704198 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag TBXG_RS03165 Protein ID WP_003403187.1
Coordinates 703797..704198 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag TBXG_RS03160 Protein ID WP_003403184.1
Coordinates 703555..703800 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS03125 698835..699365 - 531 WP_003917320.1 two component system sensor kinase HK2 -
TBXG_RS03130 699349..700044 - 696 WP_003918099.1 two-component system response regulator TcrA -
TBXG_RS03135 700167..700478 + 312 WP_003403164.1 hypothetical protein -
TBXG_RS03140 700550..701500 + 951 WP_003900184.1 DUF1259 domain-containing protein -
TBXG_RS03145 701741..702325 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
TBXG_RS03150 702327..703040 + 714 Protein_626 IS607 family element transposase accessory protein TnpB -
TBXG_RS03155 703040..703510 + 471 WP_003898523.1 hypothetical protein -
TBXG_RS03160 703555..703800 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBXG_RS03165 703797..704198 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
TBXG_RS22015 704586..704753 - 168 WP_077385191.1 DUF3800 domain-containing protein -
TBXG_RS22020 704786..704983 - 198 WP_003403191.1 hypothetical protein -
TBXG_RS03180 705063..706220 - 1158 WP_003898524.1 hypothetical protein -
TBXG_RS03185 706272..706493 - 222 WP_003898525.1 DUF4926 domain-containing protein -
TBXG_RS03190 706635..707240 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T27946 WP_003403187.1 NC_018078:703797-704198 [Mycobacterium tuberculosis KZN 605]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T27946 NC_018078:703797-704198 [Mycobacterium tuberculosis KZN 605]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT27946 WP_003403184.1 NC_018078:703555-703800 [Mycobacterium tuberculosis KZN 605]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT27946 NC_018078:703555-703800 [Mycobacterium tuberculosis KZN 605]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References