Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4180802..4181456 Replicon chromosome
Accession NZ_CP124328
Organism Escherichia coli strain AVS0787

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP62_RS20825 Protein ID WP_000244765.1
Coordinates 4181049..4181456 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP62_RS20820 Protein ID WP_000354050.1
Coordinates 4180802..4181068 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP62_RS20800 (4176890) 4176890..4178323 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QJP62_RS20805 (4178368) 4178368..4178679 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP62_RS20810 (4178843) 4178843..4179502 + 660 WP_000250275.1 hemolysin III family protein -
QJP62_RS20815 (4179579) 4179579..4180559 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP62_RS20820 (4180802) 4180802..4181068 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP62_RS20825 (4181049) 4181049..4181456 + 408 WP_000244765.1 protein YgfX Toxin
QJP62_RS20830 (4181496) 4181496..4182017 - 522 WP_001055874.1 flavodoxin FldB -
QJP62_RS20835 (4182129) 4182129..4183025 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP62_RS20840 (4183050) 4183050..4183760 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP62_RS20845 (4183766) 4183766..4185499 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279458 WP_000244765.1 NZ_CP124328:4181049-4181456 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279458 WP_000354050.1 NZ_CP124328:4180802-4181068 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References