Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3517451..3518251 Replicon chromosome
Accession NZ_CP124328
Organism Escherichia coli strain AVS0787

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP62_RS17440 Protein ID WP_000342452.1
Coordinates 3517724..3518251 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP62_RS17435 Protein ID WP_001277107.1
Coordinates 3517451..3517717 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP62_RS17415 (3513110) 3513110..3513778 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QJP62_RS17420 (3513771) 3513771..3514829 + 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP62_RS17425 (3515074) 3515074..3515928 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP62_RS17430 (3516199) 3516199..3517302 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP62_RS17435 (3517451) 3517451..3517717 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP62_RS17440 (3517724) 3517724..3518251 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP62_RS17445 (3518248) 3518248..3518631 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP62_RS17450 (3519054) 3519054..3520163 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP62_RS17455 (3520211) 3520211..3521137 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP62_RS17460 (3521134) 3521134..3522411 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP62_RS17465 (3522408) 3522408..3523175 + 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279454 WP_000342452.1 NZ_CP124328:3517724-3518251 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279454 WP_001277107.1 NZ_CP124328:3517451-3517717 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References