Detailed information of TA system TA279446

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1922960..1924649
• Replicon: chromosome
• Accession: NZ_CP124328
• Organism: Escherichia coli strain AVS0787

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP62_RS09875
• Protein ID: WP_000365807.1
• Coordinates: 1922960..1923880 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP62_RS09880
• Protein ID: WP_001295795.1
• Coordinates: 1923867..1924649 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP62_RS09835 (1918433)	1918433..1919143	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP62_RS09840 (1919450)	1919450..1919779	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP62_RS09845 (1919791)	1919791..1919957	-	167	Protein_1939	tail fiber assembly protein	-
QJP62_RS09850 (1920028)	1920028..1920642	-	615	WP_001019923.1	YagU family protein	-
QJP62_RS09855 (1920857)	1920857..1921042	-	186	WP_000146240.1	hypothetical protein	-
QJP62_RS09860 (1921091)	1921091..1921249	+	159	Protein_1942	integrase	-
QJP62_RS09865 (1921476)	1921476..1921811	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP62_RS09870 (1922019)	1922019..1922795	+	777	WP_282503822.1	site-specific integrase	-
QJP62_RS09875 (1922960)	1922960..1923880	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP62_RS09880 (1923867)	1923867..1924649	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP62_RS09885 (1924933)	1924933..1928031	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	1882744..1931712	48968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279446 WP_000365807.1 NZ_CP124328:c1923880-1922960 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279446 WP_001295795.1 NZ_CP124328:c1924649-1923867 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0