Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1739653..1740271 Replicon chromosome
Accession NZ_CP124328
Organism Escherichia coli strain AVS0787

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP62_RS09015 Protein ID WP_001291435.1
Coordinates 1740053..1740271 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP62_RS09010 Protein ID WP_000344800.1
Coordinates 1739653..1740027 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP62_RS09000 (1734742) 1734742..1735935 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP62_RS09005 (1735958) 1735958..1739107 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP62_RS09010 (1739653) 1739653..1740027 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP62_RS09015 (1740053) 1740053..1740271 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP62_RS09020 (1740445) 1740445..1740996 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP62_RS09025 (1741112) 1741112..1741582 + 471 WP_000136192.1 YlaC family protein -
QJP62_RS09030 (1741746) 1741746..1743296 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP62_RS09035 (1743338) 1743338..1743691 - 354 WP_000878135.1 DUF1428 family protein -
QJP62_RS09045 (1744070) 1744070..1744381 + 312 WP_000409908.1 MGMT family protein -
QJP62_RS09050 (1744412) 1744412..1744984 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279445 WP_001291435.1 NZ_CP124328:1740053-1740271 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279445 WP_000344800.1 NZ_CP124328:1739653-1740027 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References