Detailed information of TA system TA279431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3815169..3816858
• Replicon: chromosome
• Accession: NZ_CP124326
• Organism: Escherichia coli strain AVS0285

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP69_RS18680
• Protein ID: WP_000365807.1
• Coordinates: 3815169..3816089 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP69_RS18685
• Protein ID: WP_001295795.1
• Coordinates: 3816076..3816858 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP69_RS18640 (3810642)	3810642..3811352	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP69_RS18645 (3811659)	3811659..3811988	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP69_RS18650 (3812000)	3812000..3812166	-	167	Protein_3660	tail fiber assembly protein	-
QJP69_RS18655 (3812237)	3812237..3812851	-	615	WP_001019923.1	YagU family protein	-
QJP69_RS18660 (3813066)	3813066..3813251	-	186	WP_000146240.1	hypothetical protein	-
QJP69_RS18665 (3813300)	3813300..3813458	+	159	Protein_3663	integrase	-
QJP69_RS18670 (3813685)	3813685..3814020	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP69_RS18675 (3814228)	3814228..3815004	+	777	WP_000171155.1	site-specific integrase	-
QJP69_RS18680 (3815169)	3815169..3816089	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP69_RS18685 (3816076)	3816076..3816858	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP69_RS18690 (3817142)	3817142..3820240	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3774179..3823921	49742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279431 WP_000365807.1 NZ_CP124326:c3816089-3815169 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279431 WP_001295795.1 NZ_CP124326:c3816858-3816076 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0