Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2023538..2024369 Replicon chromosome
Accession NZ_CP124326
Organism Escherichia coli strain AVS0285

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag QJP69_RS09670 Protein ID WP_000854814.1
Coordinates 2023538..2023912 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag QJP69_RS09675 Protein ID WP_001546021.1
Coordinates 2024001..2024369 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP69_RS09635 (2019533) 2019533..2019862 + 330 WP_000450409.1 DUF496 family protein -
QJP69_RS09640 (2019963) 2019963..2020286 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
QJP69_RS09645 (2020265) 2020265..2020345 + 81 WP_023441679.1 hypothetical protein -
QJP69_RS09650 (2020556) 2020556..2022097 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
QJP69_RS09655 (2022112) 2022112..2022858 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
QJP69_RS09660 (2023221) 2023221..2023301 - 81 Protein_1896 hypothetical protein -
QJP69_RS09665 (2023347) 2023347..2023541 - 195 WP_000988601.1 DUF5983 family protein -
QJP69_RS09670 (2023538) 2023538..2023912 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QJP69_RS09675 (2024001) 2024001..2024369 - 369 WP_001546021.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
QJP69_RS09680 (2024449) 2024449..2024670 - 222 WP_000692323.1 DUF987 domain-containing protein -
QJP69_RS09685 (2024733) 2024733..2025209 - 477 WP_001186773.1 RadC family protein -
QJP69_RS09690 (2025225) 2025225..2025698 - 474 WP_001385393.1 antirestriction protein -
QJP69_RS09695 (2025961) 2025961..2026782 - 822 WP_001234710.1 DUF932 domain-containing protein -
QJP69_RS09700 (2027003) 2027003..2027413 - 411 WP_000846704.1 hypothetical protein -
QJP69_RS09705 (2027429) 2027429..2028106 - 678 WP_001362823.1 hypothetical protein -
QJP69_RS09710 (2028242) 2028242..2029312 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T279422 WP_000854814.1 NZ_CP124326:c2023912-2023538 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT279422 WP_001546021.1 NZ_CP124326:c2024369-2024001 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References