Detailed information of TA system TA279409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3816333..3818022
• Replicon: chromosome
• Accession: NZ_CP124324
• Organism: Escherichia coli strain AVS0536

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP54_RS18665
• Protein ID: WP_000365807.1
• Coordinates: 3816333..3817253 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP54_RS18670
• Protein ID: WP_001295795.1
• Coordinates: 3817240..3818022 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP54_RS18625 (3811806)	3811806..3812516	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP54_RS18630 (3812823)	3812823..3813152	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP54_RS18635 (3813164)	3813164..3813330	-	167	Protein_3661	tail fiber assembly protein	-
QJP54_RS18640 (3813401)	3813401..3814015	-	615	WP_001019923.1	YagU family protein	-
QJP54_RS18645 (3814230)	3814230..3814415	-	186	WP_000146240.1	hypothetical protein	-
QJP54_RS18650 (3814464)	3814464..3814622	+	159	Protein_3664	integrase	-
QJP54_RS18655 (3814849)	3814849..3815184	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP54_RS18660 (3815392)	3815392..3816168	+	777	WP_000171155.1	site-specific integrase	-
QJP54_RS18665 (3816333)	3816333..3817253	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP54_RS18670 (3817240)	3817240..3818022	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP54_RS18675 (3818306)	3818306..3821404	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3775343..3825085	49742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279409 WP_000365807.1 NZ_CP124324:c3817253-3816333 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279409 WP_001295795.1 NZ_CP124324:c3818022-3817240 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0