Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2964362..2964833 Replicon chromosome
Accession NZ_CP124324
Organism Escherichia coli strain AVS0536

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP54_RS14595 Protein ID WP_001303511.1
Coordinates 2964555..2964833 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP54_RS14590 Protein ID WP_001302048.1
Coordinates 2964362..2964553 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP54_RS14520 (2959429) 2959429..2959596 - 168 WP_000207997.1 hypothetical protein -
QJP54_RS14525 (2959607) 2959607..2959870 - 264 WP_000224216.1 hypothetical protein -
QJP54_RS14530 (2959872) 2959872..2960090 - 219 WP_001142588.1 DUF4014 family protein -
QJP54_RS14535 (2960092) 2960092..2960307 - 216 WP_000510387.1 hypothetical protein -
QJP54_RS14540 (2960308) 2960308..2960667 - 360 WP_001289986.1 hypothetical protein -
QJP54_RS14545 (2960664) 2960664..2960840 - 177 WP_021534704.1 hypothetical protein -
QJP54_RS14550 (2960833) 2960833..2961015 - 183 WP_001224665.1 hypothetical protein -
QJP54_RS14555 (2961144) 2961144..2961455 - 312 WP_021534703.1 hypothetical protein -
QJP54_RS14560 (2961448) 2961448..2961702 - 255 WP_000004322.1 hypothetical protein -
QJP54_RS14565 (2961699) 2961699..2962121 - 423 WP_021534702.1 DUF977 family protein -
QJP54_RS14570 (2962162) 2962162..2963124 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP54_RS14575 (2963147) 2963147..2963572 - 426 WP_000693943.1 toxin YdaT family protein -
QJP54_RS14580 (2963569) 2963569..2963871 - 303 WP_000172738.1 transcriptional regulator -
QJP54_RS14585 (2963970) 2963970..2964341 + 372 WP_001169687.1 hypothetical protein -
QJP54_RS14590 (2964362) 2964362..2964553 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP54_RS14595 (2964555) 2964555..2964833 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP54_RS14600 (2965125) 2965125..2965277 + 153 WP_000380313.1 DUF1391 family protein -
QJP54_RS14605 (2965289) 2965289..2965627 + 339 WP_000394541.1 hypothetical protein -
QJP54_RS14610 (2965616) 2965616..2965810 - 195 WP_001295058.1 hypothetical protein -
QJP54_RS14615 (2966377) 2966377..2966565 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP54_RS14620 (2966562) 2966562..2966750 + 189 WP_000199480.1 DUF1482 family protein -
QJP54_RS14625 (2966846) 2966846..2969317 + 2472 WP_032284123.1 exonuclease -
QJP54_RS14630 (2969379) 2969379..2969648 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2946135..2974043 27908
- inside Prophage sitABCD - 2829282..2977903 148621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279406 WP_001303511.1 NZ_CP124324:2964555-2964833 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279406 WP_001302048.1 NZ_CP124324:2964362-2964553 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References