Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2024926..2025757 Replicon chromosome
Accession NZ_CP124324
Organism Escherichia coli strain AVS0536

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag QJP54_RS09665 Protein ID WP_000854814.1
Coordinates 2024926..2025300 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag QJP54_RS09670 Protein ID WP_001546021.1
Coordinates 2025389..2025757 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP54_RS09630 (2020921) 2020921..2021250 + 330 WP_000450409.1 DUF496 family protein -
QJP54_RS09635 (2021351) 2021351..2021674 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
QJP54_RS09640 (2021653) 2021653..2021733 + 81 WP_023441679.1 hypothetical protein -
QJP54_RS09645 (2021944) 2021944..2023485 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
QJP54_RS09650 (2023500) 2023500..2024246 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
QJP54_RS09655 (2024609) 2024609..2024689 - 81 Protein_1897 hypothetical protein -
QJP54_RS09660 (2024735) 2024735..2024929 - 195 WP_000988601.1 DUF5983 family protein -
QJP54_RS09665 (2024926) 2024926..2025300 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QJP54_RS09670 (2025389) 2025389..2025757 - 369 WP_001546021.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
QJP54_RS09675 (2025837) 2025837..2026058 - 222 WP_000692323.1 DUF987 domain-containing protein -
QJP54_RS09680 (2026121) 2026121..2026597 - 477 WP_001186773.1 RadC family protein -
QJP54_RS09685 (2026613) 2026613..2027086 - 474 WP_001385393.1 antirestriction protein -
QJP54_RS09690 (2027349) 2027349..2028170 - 822 WP_001234710.1 DUF932 domain-containing protein -
QJP54_RS09695 (2028391) 2028391..2028801 - 411 WP_000846704.1 hypothetical protein -
QJP54_RS09700 (2028817) 2028817..2029494 - 678 WP_001362823.1 hypothetical protein -
QJP54_RS09705 (2029630) 2029630..2030700 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T279400 WP_000854814.1 NZ_CP124324:c2025300-2024926 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT279400 WP_001546021.1 NZ_CP124324:c2025757-2025389 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References