Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4127299..4127953 Replicon chromosome
Accession NZ_CP124320
Organism Escherichia coli strain AVS0754

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP81_RS20055 Protein ID WP_000244765.1
Coordinates 4127299..4127706 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP81_RS20060 Protein ID WP_000354050.1
Coordinates 4127687..4127953 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP81_RS20035 (4123256) 4123256..4124989 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP81_RS20040 (4124995) 4124995..4125705 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP81_RS20045 (4125730) 4125730..4126626 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP81_RS20050 (4126738) 4126738..4127259 + 522 WP_001055874.1 flavodoxin FldB -
QJP81_RS20055 (4127299) 4127299..4127706 - 408 WP_000244765.1 protein YgfX Toxin
QJP81_RS20060 (4127687) 4127687..4127953 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP81_RS20065 (4128196) 4128196..4129176 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QJP81_RS20070 (4129253) 4129253..4129912 - 660 WP_000250275.1 hemolysin III family protein -
QJP81_RS20075 (4130076) 4130076..4130387 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP81_RS20080 (4130432) 4130432..4131865 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279367 WP_000244765.1 NZ_CP124320:c4127706-4127299 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279367 WP_000354050.1 NZ_CP124320:c4127953-4127687 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References