Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1562086..1562704 Replicon chromosome
Accession NZ_CP124320
Organism Escherichia coli strain AVS0754

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP81_RS07545 Protein ID WP_001291435.1
Coordinates 1562086..1562304 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP81_RS07550 Protein ID WP_000344800.1
Coordinates 1562330..1562704 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP81_RS07510 (1557374) 1557374..1557946 + 573 WP_000779841.1 YbaY family lipoprotein -
QJP81_RS07515 (1557977) 1557977..1558288 - 312 WP_000409908.1 MGMT family protein -
QJP81_RS07525 (1558667) 1558667..1559020 + 354 WP_000878147.1 DUF1428 family protein -
QJP81_RS07530 (1559062) 1559062..1560612 - 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP81_RS07535 (1560776) 1560776..1561246 - 471 WP_000136192.1 YlaC family protein -
QJP81_RS07540 (1561362) 1561362..1561913 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP81_RS07545 (1562086) 1562086..1562304 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP81_RS07550 (1562330) 1562330..1562704 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP81_RS07555 (1563250) 1563250..1566399 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP81_RS07560 (1566422) 1566422..1567615 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279354 WP_001291435.1 NZ_CP124320:c1562304-1562086 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279354 WP_000344800.1 NZ_CP124320:c1562704-1562330 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References