Detailed information of TA system TA279353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1377726..1379415
• Replicon: chromosome
• Accession: NZ_CP124320
• Organism: Escherichia coli strain AVS0754

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP81_RS06685
• Protein ID: WP_000365807.1
• Coordinates: 1378495..1379415 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP81_RS06680
• Protein ID: WP_001295795.1
• Coordinates: 1377726..1378508 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP81_RS06675 (1374344)	1374344..1377442	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP81_RS06680 (1377726)	1377726..1378508	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP81_RS06685 (1378495)	1378495..1379415	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP81_RS06690 (1379580)	1379580..1380356	-	777	WP_000171155.1	site-specific integrase	-
QJP81_RS06695 (1380564)	1380564..1380899	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP81_RS06700 (1381126)	1381126..1381284	-	159	Protein_1316	integrase	-
QJP81_RS06705 (1381333)	1381333..1381518	+	186	WP_000146240.1	hypothetical protein	-
QJP81_RS06710 (1381733)	1381733..1382347	+	615	WP_001019923.1	YagU family protein	-
QJP81_RS06715 (1382418)	1382418..1382584	+	167	Protein_1319	tail fiber assembly protein	-
QJP81_RS06720 (1382596)	1382596..1382925	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP81_RS06725 (1383232)	1383232..1383942	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	1370663..1419628	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279353 WP_000365807.1 NZ_CP124320:1378495-1379415 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279353 WP_001295795.1 NZ_CP124320:1377726-1378508 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0