Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1039595..1040171 Replicon chromosome
Accession NZ_CP124320
Organism Escherichia coli strain AVS0754

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP81_RS05070 Protein ID WP_001297643.1
Coordinates 1039595..1039882 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP81_RS05075 Protein ID WP_000063156.1
Coordinates 1039869..1040171 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP81_RS05050 (1035848) 1035848..1037128 - 1281 WP_001037382.1 DUF445 domain-containing protein -
QJP81_RS05055 (1037169) 1037169..1038401 - 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP81_RS05060 (1038547) 1038547..1038642 - 96 Protein_999 dienelactone hydrolase family protein -
QJP81_RS05065 (1038699) 1038699..1039396 + 698 Protein_1000 IS1 family transposase -
QJP81_RS05070 (1039595) 1039595..1039882 + 288 WP_001297643.1 BrnT family toxin Toxin
QJP81_RS05075 (1039869) 1039869..1040171 + 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP81_RS05080 (1040205) 1040205..1041161 - 957 WP_001297640.1 GTPase -
QJP81_RS05085 (1041172) 1041172..1041375 - 204 WP_000467859.1 YbdD/YjiX family protein -
QJP81_RS05090 (1041425) 1041425..1043575 - 2151 WP_001295524.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T279351 WP_001297643.1 NZ_CP124320:1039595-1039882 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT279351 WP_000063156.1 NZ_CP124320:1039869-1040171 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References