Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 968481..969315 Replicon chromosome
Accession NZ_CP124320
Organism Escherichia coli strain AVS0754

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1J6XFW9
Locus tag QJP81_RS04700 Protein ID WP_000854770.1
Coordinates 968938..969315 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1N885
Locus tag QJP81_RS04695 Protein ID WP_001280950.1
Coordinates 968481..968849 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP81_RS04665 (963633) 963633..965534 + 1902 Protein_920 Ag43/Cah family autotransporter adhesin -
QJP81_RS04670 (965605) 965605..965800 + 196 Protein_921 DUF905 family protein -
QJP81_RS04675 (965918) 965918..966736 + 819 WP_001234712.1 DUF932 domain-containing protein -
QJP81_RS04680 (967078) 967078..967542 + 465 WP_000855061.1 antirestriction protein -
QJP81_RS04685 (967558) 967558..968034 + 477 WP_001186779.1 RadC family protein -
QJP81_RS04690 (968097) 968097..968318 + 222 WP_001220314.1 DUF987 domain-containing protein -
QJP81_RS04695 (968481) 968481..968849 + 369 WP_001280950.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QJP81_RS04700 (968938) 968938..969315 + 378 WP_000854770.1 TA system toxin CbtA family protein Toxin
QJP81_RS04705 (969312) 969312..969800 + 489 WP_000761690.1 DUF5983 family protein -
QJP81_RS04710 (969817) 969817..969993 + 177 WP_000839286.1 DUF957 domain-containing protein -
QJP81_RS04715 (970099) 970099..970248 + 150 Protein_930 hypothetical protein -
QJP81_RS04720 (970615) 970615..970920 + 306 Protein_931 helix-turn-helix domain-containing protein -
QJP81_RS04725 (971582) 971582..973204 + 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 920468..980961 60493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14196.37 Da        Isoelectric Point: 8.7438

>T279350 WP_000854770.1 NZ_CP124320:968938-969315 [Escherichia coli]
MKTLPDTHVRKVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13737.56 Da        Isoelectric Point: 7.0268

>AT279350 WP_001280950.1 NZ_CP124320:968481-968849 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAFYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6XFW9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1N885

References