Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 782845..783470 Replicon chromosome
Accession NC_018068
Organism Desulfosporosinus acidiphilus SJ4

Toxin (Protein)


Gene name pemK Uniprot ID I4D1Y5
Locus tag DESACI_RS03650 Protein ID WP_014825820.1
Coordinates 783120..783470 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I4D1Y4
Locus tag DESACI_RS03645 Protein ID WP_014825819.1
Coordinates 782845..783123 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DESACI_RS03625 778460..779710 + 1251 WP_014825815.1 NAD(P)/FAD-dependent oxidoreductase -
DESACI_RS03630 779796..780053 + 258 WP_014825816.1 hypothetical protein -
DESACI_RS03635 780414..781820 + 1407 WP_014825817.1 DUF1727 domain-containing protein -
DESACI_RS03640 781817..782596 + 780 WP_014825818.1 glutamine amidotransferase -
DESACI_RS03645 782845..783123 + 279 WP_014825819.1 ribbon-helix-helix protein, CopG family Antitoxin
DESACI_RS03650 783120..783470 + 351 WP_014825820.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DESACI_RS03655 783560..784267 + 708 WP_014825821.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
DESACI_RS03660 784828..785049 + 222 WP_014825822.1 SHOCT domain-containing protein -
DESACI_RS03665 785107..785394 + 288 WP_041275955.1 SHOCT domain-containing protein -
DESACI_RS03670 785531..786277 - 747 WP_014825824.1 precorrin-6A/cobalt-precorrin-6A reductase -
DESACI_RS03675 786580..787731 + 1152 WP_014825825.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-39)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12852.88 Da        Isoelectric Point: 5.8945

>T27934 WP_014825820.1 NC_018068:783120-783470 [Desulfosporosinus acidiphilus SJ4]
MIIKRGEIYYAELNPVVGSEQGGTRPVLVIQNDIGNQFSPTTIIAAITSQIAKAKLPTHVEVRARRSGLERDSVILTEQI
RTIDKSRLKEKVTVLDEEVMLRVDQAIEISLGLADI

Download         Length: 351 bp

>T27934 NC_018068:783120-783470 [Desulfosporosinus acidiphilus SJ4]
ATGATCATAAAACGCGGGGAAATTTATTATGCAGAACTAAACCCCGTTGTCGGCTCAGAACAGGGAGGAACTCGTCCGGT
CCTCGTGATTCAAAACGACATAGGGAATCAATTCAGTCCAACCACAATCATTGCTGCGATTACATCACAAATTGCAAAAG
CAAAGTTACCTACACATGTTGAAGTTAGAGCCCGACGTAGCGGTTTAGAAAGAGACTCCGTCATTCTTACCGAACAAATC
CGAACCATCGATAAAAGTCGCCTGAAGGAAAAGGTGACAGTTCTTGATGAGGAAGTAATGCTTAGGGTGGACCAAGCCAT
TGAGATTAGTCTAGGGTTGGCTGATATTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10895.59 Da        Isoelectric Point: 5.7841

>AT27934 WP_014825819.1 NC_018068:782845-783123 [Desulfosporosinus acidiphilus SJ4]
VAESKRIMISLPESLLAEVDGIVTVEKRNRSEFIREALNSILHERRKKGIHEQMRKGYLEMAQLNLSIARELFLTEQEVL
EYYEETMVECRR

Download         Length: 279 bp

>AT27934 NC_018068:782845-783123 [Desulfosporosinus acidiphilus SJ4]
GTGGCAGAGAGTAAGCGGATTATGATCAGTTTGCCGGAAAGTTTGCTTGCAGAAGTGGACGGAATCGTCACGGTGGAAAA
ACGCAATCGCAGTGAATTTATCCGAGAAGCACTCAACAGCATTCTTCACGAGCGTCGCAAAAAAGGAATTCATGAACAAA
TGCGCAAAGGATATCTTGAAATGGCGCAACTCAATTTGTCGATTGCCAGAGAACTTTTCTTAACAGAACAAGAAGTATTA
GAGTATTATGAAGAAACGATGGTGGAGTGTCGGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1FP71

Antitoxin

Source ID Structure
AlphaFold DB I4D1Y4

References