Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2573647..2575235 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag QG930_RS12210 Protein ID WP_004892016.1
Coordinates 2573913..2575235 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QG930_RS12205 Protein ID WP_004176198.1
Coordinates 2573647..2573913 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS12180 (QG930_12180) 2568798..2569721 + 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -
QG930_RS12185 (QG930_12185) 2569702..2570856 - 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
QG930_RS12190 (QG930_12190) 2571202..2572581 + 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
QG930_RS12195 (QG930_12195) 2572559..2573059 + 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QG930_RS12200 (QG930_12200) 2573056..2573382 + 327 WP_004892019.1 hydroxyisourate hydrolase -
QG930_RS12205 (QG930_12205) 2573647..2573913 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QG930_RS12210 (QG930_12210) 2573913..2575235 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
QG930_RS12215 (QG930_12215) 2575252..2576544 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QG930_RS12220 (QG930_12220) 2576686..2577690 - 1005 WP_004892012.1 fimbrial protein -
QG930_RS12225 (QG930_12225) 2577678..2580179 - 2502 WP_004892009.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iroE / mgtC 2538164..2764589 226425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T279336 WP_004892016.1 NZ_CP124220:2573913-2575235 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT279336 WP_004176198.1 NZ_CP124220:2573647-2573913 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References