279334

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1259310..1259929 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QG930_RS06000 Protein ID WP_002892050.1
Coordinates 1259310..1259528 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag QG930_RS06005 Protein ID WP_002892066.1
Coordinates 1259555..1259929 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS05965 (QG930_05965) 1255357..1255620 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
QG930_RS05970 (QG930_05970) 1255620..1255760 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
QG930_RS05975 (QG930_05975) 1255757..1256455 - 699 WP_004893822.1 GNAT family protein -
QG930_RS05980 (QG930_05980) 1256556..1258007 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
QG930_RS05985 (QG930_05985) 1257982..1258452 - 471 WP_002892026.1 YlaC family protein -
QG930_RS05990 (QG930_05990) 1258473..1258613 + 141 WP_032409038.1 hypothetical protein -
QG930_RS05995 (QG930_05995) 1258585..1259151 - 567 WP_002892030.1 maltose O-acetyltransferase -
QG930_RS06000 (QG930_06000) 1259310..1259528 - 219 WP_002892050.1 HHA domain-containing protein Toxin
QG930_RS06005 (QG930_06005) 1259555..1259929 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
QG930_RS06010 (QG930_06010) 1260415..1263561 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
QG930_RS06015 (QG930_06015) 1263584..1264777 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279334 WP_002892050.1 NZ_CP124220:c1259528-1259310 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT279334 WP_002892066.1 NZ_CP124220:c1259929-1259555 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References