279333

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 648360..649170 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag QG930_RS03065 Protein ID WP_004178461.1
Coordinates 648637..649170 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QG930_RS03060 Protein ID WP_002887278.1
Coordinates 648360..648626 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS03040 (QG930_03040) 644232..644576 - 345 WP_004894569.1 cation efflux system protein CusF -
QG930_RS03045 (QG930_03045) 644594..645979 - 1386 WP_004894567.1 efflux transporter outer membrane subunit -
QG930_RS03050 (QG930_03050) 646151..646834 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
QG930_RS03055 (QG930_03055) 646824..648257 + 1434 WP_004894565.1 Cu(+)/Ag(+) sensor histidine kinase -
QG930_RS03060 (QG930_03060) 648360..648626 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QG930_RS03065 (QG930_03065) 648637..649170 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
QG930_RS03070 (QG930_03070) 649218..650339 - 1122 WP_002887282.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T279333 WP_004178461.1 NZ_CP124220:648637-649170 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT279333 WP_002887278.1 NZ_CP124220:648360-648626 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References