Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 612940..613643 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag QG930_RS02895 Protein ID WP_017880111.1
Coordinates 613302..613643 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag QG930_RS02890 Protein ID WP_050131139.1
Coordinates 612940..613281 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS02855 (QG930_02855) 608090..608965 + 876 WP_017880120.1 GTPase family protein -
QG930_RS02860 (QG930_02860) 609209..609925 + 717 WP_032417794.1 WYL domain-containing protein -
QG930_RS02865 (QG930_02865) 609961..610413 + 453 WP_031280325.1 hypothetical protein -
QG930_RS02870 (QG930_02870) 610485..610958 + 474 WP_031280324.1 hypothetical protein -
QG930_RS02875 (QG930_02875) 611079..611900 + 822 WP_017880115.1 DUF932 domain-containing protein -
QG930_RS02880 (QG930_02880) 611931..612374 + 444 WP_017880114.1 antirestriction protein -
QG930_RS02885 (QG930_02885) 612387..612929 + 543 WP_017880113.1 DNA repair protein RadC -
QG930_RS02890 (QG930_02890) 612940..613281 + 342 WP_050131139.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QG930_RS02895 (QG930_02895) 613302..613643 + 342 WP_017880111.1 TA system toxin CbtA family protein Toxin
QG930_RS02900 (QG930_02900) 613907..614914 + 1008 WP_017880110.1 restriction endonuclease -
QG930_RS02905 (QG930_02905) 615289..615399 + 111 Protein_547 DUF4102 domain-containing protein -
QG930_RS02910 (QG930_02910) 615412..615546 - 135 Protein_548 transposase -
QG930_RS02915 (QG930_02915) 615692..615955 - 264 WP_004192273.1 hypothetical protein -
QG930_RS02920 (QG930_02920) 615945..617072 - 1128 WP_023325431.1 PAAR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 578559..618825 40266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12811.73 Da        Isoelectric Point: 8.4941

>T279332 WP_017880111.1 NZ_CP124220:613302-613643 [Klebsiella pneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDIMRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12821.45 Da        Isoelectric Point: 6.3148

>AT279332 WP_050131139.1 NZ_CP124220:612940-613281 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNCNMTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References