Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 518996..519512 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag QG930_RS02470 Protein ID WP_004894697.1
Coordinates 519228..519512 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QG930_RS02465 Protein ID WP_002886901.1
Coordinates 518996..519238 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS02450 (QG930_02450) 515024..515764 + 741 WP_002886899.1 KDGP aldolase family protein -
QG930_RS02455 (QG930_02455) 515831..516985 + 1155 WP_004178372.1 lactonase family protein -
QG930_RS02460 (QG930_02460) 517008..518918 + 1911 WP_281471315.1 PRD domain-containing protein -
QG930_RS02465 (QG930_02465) 518996..519238 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QG930_RS02470 (QG930_02470) 519228..519512 + 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QG930_RS02475 (QG930_02475) 519516..519980 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QG930_RS02480 (QG930_02480) 520309..522447 - 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
QG930_RS02485 (QG930_02485) 522805..523548 - 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
QG930_RS02490 (QG930_02490) 523551..523724 - 174 WP_002886906.1 hypothetical protein -
QG930_RS02495 (QG930_02495) 523854..524117 + 264 WP_031280360.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T279330 WP_004894697.1 NZ_CP124220:519228-519512 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT279330 WP_002886901.1 NZ_CP124220:518996-519238 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References