27933

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 3976382..3976859 Replicon chromosome
Accession NC_018028
Organism Pseudomonas stutzeri CCUG 29243

Toxin (Protein)


Gene name pasB Uniprot ID I4CXW4
Locus tag A458_RS40310 Protein ID WP_014821700.1
Coordinates 3976382..3976648 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A5C8YM66
Locus tag A458_RS40315 Protein ID WP_041754822.1
Coordinates 3976632..3976859 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A458_RS40300 3974712..3975455 + 744 WP_014821698.1 hypothetical protein -
A458_RS40305 3975452..3976261 + 810 WP_014821699.1 DUF3037 domain-containing protein -
A458_RS40310 3976382..3976648 - 267 WP_014821700.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A458_RS40315 3976632..3976859 - 228 WP_041754822.1 CopG family transcriptional regulator Antitoxin
A458_RS40320 3977284..3977505 + 222 WP_014821702.1 transcriptional regulator -
A458_RS40325 3977660..3978430 + 771 WP_014821703.1 NERD domain-containing protein -
A458_RS40330 3978542..3979639 + 1098 WP_014821704.1 nucleoid-associated protein -
A458_RS40335 3979639..3980622 + 984 WP_148273161.1 RelA/SpoT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3970828..3980622 9794


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10229.78 Da        Isoelectric Point: 10.2748

>T27933 WP_014821700.1 NC_018028:c3976648-3976382 [Pseudomonas stutzeri CCUG 29243]
MAWTIDYTDTAKTQLRKLDKQSAKRILDFMDERVSSRDDPRTTGKALTGPLGGLWRYRVGDFRVICEIQDGALRILVLQL
GNRREIYR

Download         Length: 267 bp

>T27933 NC_018028:c3976648-3976382 [Pseudomonas stutzeri CCUG 29243]
TTGGCTTGGACGATTGATTACACCGACACGGCCAAAACACAGTTGCGTAAGCTCGACAAACAGTCAGCGAAGCGCATTCT
TGACTTTATGGATGAGCGGGTGTCCAGCCGGGATGACCCGAGAACCACTGGCAAGGCGCTTACAGGCCCATTGGGTGGCT
TGTGGCGGTATCGCGTAGGAGACTTCCGGGTGATCTGCGAGATTCAGGACGGGGCCTTGCGGATACTCGTCCTACAGCTT
GGCAACCGCCGAGAAATTTACCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8441.52 Da        Isoelectric Point: 4.6158

>AT27933 WP_041754822.1 NC_018028:c3976859-3976632 [Pseudomonas stutzeri CCUG 29243]
MATSIRLAPEVEQRLDFLAASTGRTKAYYLREIIDNGLADLEDYYLAAEVLERVRKKTEAVHSAADVRKDLGLDD

Download         Length: 228 bp

>AT27933 NC_018028:c3976859-3976632 [Pseudomonas stutzeri CCUG 29243]
ATGGCCACTTCCATCAGATTGGCACCCGAAGTTGAGCAGCGCCTAGATTTTCTGGCGGCCAGCACTGGGCGTACCAAGGC
GTATTATCTGCGTGAAATCATCGATAACGGCCTGGCTGACCTTGAGGACTACTACCTCGCGGCTGAAGTCCTGGAGCGTG
TCCGTAAAAAAACAGAGGCCGTTCACTCTGCTGCGGACGTAAGGAAAGACCTTGGCTTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I4CXW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5C8YM66

References