279329

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 44673..45298 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QG930_RS00205 Protein ID WP_002882817.1
Coordinates 44915..45298 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QG930_RS00200 Protein ID WP_004150355.1
Coordinates 44673..44915 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS00175 (QG930_00175) 40664..41263 + 600 WP_004151865.1 glucose-1-phosphatase -
QG930_RS00180 (QG930_00180) 41257..42117 + 861 WP_004146232.1 virulence factor BrkB family protein -
QG930_RS00185 (QG930_00185) 42114..42551 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QG930_RS00190 (QG930_00190) 42596..43537 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QG930_RS00195 (QG930_00195) 43551..44468 - 918 WP_004895173.1 alpha/beta hydrolase -
QG930_RS00200 (QG930_00200) 44673..44915 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QG930_RS00205 (QG930_00205) 44915..45298 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QG930_RS00210 (QG930_00210) 45472..46401 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QG930_RS00215 (QG930_00215) 46398..47033 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QG930_RS00220 (QG930_00220) 47030..47932 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T279329 WP_002882817.1 NZ_CP124220:44915-45298 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT279329 WP_004150355.1 NZ_CP124220:44673-44915 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References