Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/FR47-DUF1778
Location 39475..40272 Replicon plasmid unnamed2
Accession NZ_CP124123
Organism Enterobacter hormaechei strain 2020CK-00198

Toxin (Protein)


Gene name KacT Uniprot ID F5S3R9
Locus tag QIW35_RS23550 Protein ID WP_006812498.1
Coordinates 39748..40272 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5S3R8
Locus tag QIW35_RS23545 Protein ID WP_006812497.1
Coordinates 39475..39744 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIW35_RS23520 (QIW35_23520) 34848..36188 - 1341 WP_006812582.1 DnaB-like helicase C-terminal domain-containing protein -
QIW35_RS23525 (QIW35_23525) 36249..36974 - 726 WP_006812583.1 hypothetical protein -
QIW35_RS23530 (QIW35_23530) 37238..38035 + 798 WP_006812584.1 DUF2971 domain-containing protein -
QIW35_RS23535 (QIW35_23535) 38077..38430 - 354 WP_160859104.1 hypothetical protein -
QIW35_RS23540 (QIW35_23540) 38436..39101 - 666 WP_023315962.1 AAA family ATPase -
QIW35_RS23545 (QIW35_23545) 39475..39744 + 270 WP_006812497.1 DUF1778 domain-containing protein Antitoxin
QIW35_RS23550 (QIW35_23550) 39748..40272 + 525 WP_006812498.1 GNAT family N-acetyltransferase Toxin
QIW35_RS23555 (QIW35_23555) 40299..40463 - 165 WP_006812499.1 hypothetical protein -
QIW35_RS23560 (QIW35_23560) 40456..40707 - 252 WP_000147960.1 hypothetical protein -
QIW35_RS23565 (QIW35_23565) 40709..41401 - 693 WP_006812500.1 membrane protein -
QIW35_RS23570 (QIW35_23570) 41415..41738 - 324 WP_000064173.1 hypothetical protein -
QIW35_RS23575 (QIW35_23575) 41813..42601 - 789 WP_032655902.1 receptor-recognizing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..113075 113075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-149)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19356.13 Da        Isoelectric Point: 8.9844

>T279327 WP_006812498.1 NZ_CP124123:39748-40272 [Enterobacter hormaechei]
VANLTIEMFSEEAVYDFSCFDCGETSLNDFLNNRLAQQHSGRILRGYLLLTRDPIPKVMGFYTLSGSCFARNTLPSNTQQ
RKVPYSDAPSVTLGRLAIDKSIQRQGYGETLVAHAMKVVYRASLAVGIYALFVDAKNENAMRFYKQLGFTPLTGDNANSL
FYPTKGIEKLFGGK

Download         Length: 525 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10114.51 Da        Isoelectric Point: 4.8483

>AT279327 WP_006812497.1 NZ_CP124123:39475-39744 [Enterobacter hormaechei]
MSALKKQRIDLRLTDDDKSMIEEAAAMTNQTITQFMVASASERAAEVIEQHRRLILSEESWNIVMDAISNPPAPNDRLKR
AAERLQSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0QWY8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0QUA3

References