Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 47057..47796 Replicon plasmid unnamed1
Accession NZ_CP124122
Organism Enterobacter hormaechei strain 2020CK-00198

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag QIW35_RS22825 Protein ID WP_045334714.1
Coordinates 47057..47542 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag QIW35_RS22830 Protein ID WP_045334712.1
Coordinates 47530..47796 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIW35_RS22810 (QIW35_22810) 43595..44035 + 441 WP_058672231.1 hypothetical protein -
QIW35_RS22815 (QIW35_22815) 44038..45192 + 1155 WP_058672230.1 hypothetical protein -
QIW35_RS22820 (QIW35_22820) 45468..46870 - 1403 Protein_47 ISNCY family transposase -
QIW35_RS22825 (QIW35_22825) 47057..47542 - 486 WP_045334714.1 GNAT family N-acetyltransferase Toxin
QIW35_RS22830 (QIW35_22830) 47530..47796 - 267 WP_045334712.1 DUF1778 domain-containing protein Antitoxin
QIW35_RS22835 (QIW35_22835) 48433..49446 + 1014 WP_045334710.1 plasmid replication initiator RepA -
QIW35_RS22840 (QIW35_22840) 50397..51203 + 807 WP_045334708.1 DUF4225 domain-containing protein -
QIW35_RS22845 (QIW35_22845) 51178..51507 - 330 WP_045334705.1 hypothetical protein -
QIW35_RS22850 (QIW35_22850) 51590..51928 - 339 WP_045334702.1 hypothetical protein -
QIW35_RS22855 (QIW35_22855) 51943..52713 - 771 WP_045334699.1 TraX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..137276 137276
- flank IS/Tn - - 45468..46160 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17607.36 Da        Isoelectric Point: 10.1390

>T279325 WP_045334714.1 NZ_CP124122:c47542-47057 [Enterobacter hormaechei]
VGRVTAPEPLTSSHQLTEFVSGEAVLDDWLKQRGLKNQALGSARTFVVCKTGTKQVVGFYSLATGSVNHVEATGNIRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEVAKSFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3721

>AT279325 WP_045334712.1 NZ_CP124122:c47796-47530 [Enterobacter hormaechei]
MKSDIQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDDAAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References