Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4652876..4653492 Replicon chromosome
Accession NZ_CP124121
Organism Enterobacter hormaechei strain 2020CK-00198

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QIW35_RS22195 Protein ID WP_015569913.1
Coordinates 4652876..4653247 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag QIW35_RS22200 Protein ID WP_015569912.1
Coordinates 4653250..4653492 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIW35_RS22180 (QIW35_22180) 4650376..4651278 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
QIW35_RS22185 (QIW35_22185) 4651275..4651910 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
QIW35_RS22190 (QIW35_22190) 4651907..4652836 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
QIW35_RS22195 (QIW35_22195) 4652876..4653247 - 372 WP_015569913.1 PIN domain-containing protein Toxin
QIW35_RS22200 (QIW35_22200) 4653250..4653492 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
QIW35_RS22205 (QIW35_22205) 4653691..4654611 + 921 WP_015569911.1 alpha/beta hydrolase -
QIW35_RS22210 (QIW35_22210) 4654620..4655561 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
QIW35_RS22215 (QIW35_22215) 4655606..4656043 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
QIW35_RS22220 (QIW35_22220) 4656040..4656921 - 882 WP_003861949.1 virulence factor BrkB family protein -
QIW35_RS22225 (QIW35_22225) 4656915..4657514 - 600 WP_017694048.1 glucose-1-phosphatase -
QIW35_RS22230 (QIW35_22230) 4657633..4658433 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T279324 WP_015569913.1 NZ_CP124121:c4653247-4652876 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT279324 WP_015569912.1 NZ_CP124121:c4653492-4653250 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References