Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3789671..3790328 Replicon chromosome
Accession NZ_CP124121
Organism Enterobacter hormaechei strain 2020CK-00198

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag QIW35_RS17995 Protein ID WP_023295382.1
Coordinates 3789671..3790081 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag QIW35_RS18000 Protein ID WP_003863437.1
Coordinates 3790062..3790328 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIW35_RS17975 (QIW35_17975) 3785669..3787402 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
QIW35_RS17980 (QIW35_17980) 3787408..3788121 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QIW35_RS17985 (QIW35_17985) 3788150..3789046 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
QIW35_RS17990 (QIW35_17990) 3789148..3789669 + 522 WP_015571793.1 flavodoxin FldB -
QIW35_RS17995 (QIW35_17995) 3789671..3790081 - 411 WP_023295382.1 protein YgfX Toxin
QIW35_RS18000 (QIW35_18000) 3790062..3790328 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
QIW35_RS18005 (QIW35_18005) 3790623..3791603 + 981 WP_039269839.1 tRNA-modifying protein YgfZ -
QIW35_RS18010 (QIW35_18010) 3791715..3792374 - 660 WP_003863433.1 hemolysin III family protein -
QIW35_RS18015 (QIW35_18015) 3792641..3793369 + 729 WP_039269836.1 MurR/RpiR family transcriptional regulator -
QIW35_RS18020 (QIW35_18020) 3793489..3794922 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T279323 WP_023295382.1 NZ_CP124121:c3790081-3789671 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT279323 WP_003863437.1 NZ_CP124121:c3790328-3790062 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References