Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1102650..1103270 Replicon chromosome
Accession NZ_CP124121
Organism Enterobacter hormaechei strain 2020CK-00198

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag QIW35_RS05175 Protein ID WP_015571250.1
Coordinates 1102650..1102868 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag QIW35_RS05180 Protein ID WP_006809850.1
Coordinates 1102896..1103270 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIW35_RS05145 (QIW35_05145) 1098662..1098922 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
QIW35_RS05150 (QIW35_05150) 1098925..1099065 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
QIW35_RS05155 (QIW35_05155) 1099062..1099772 - 711 WP_032670463.1 GNAT family protein -
QIW35_RS05160 (QIW35_05160) 1099874..1101334 + 1461 WP_039271537.1 PLP-dependent aminotransferase family protein -
QIW35_RS05165 (QIW35_05165) 1101306..1101773 - 468 WP_023296041.1 YlaC family protein -
QIW35_RS05170 (QIW35_05170) 1101890..1102441 - 552 WP_015571251.1 maltose O-acetyltransferase -
QIW35_RS05175 (QIW35_05175) 1102650..1102868 - 219 WP_015571250.1 HHA domain-containing protein Toxin
QIW35_RS05180 (QIW35_05180) 1102896..1103270 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
QIW35_RS05185 (QIW35_05185) 1103781..1106927 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
QIW35_RS05190 (QIW35_05190) 1106950..1108143 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T279316 WP_015571250.1 NZ_CP124121:c1102868-1102650 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT279316 WP_006809850.1 NZ_CP124121:c1103270-1102896 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References