Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 512984..513620 Replicon chromosome
Accession NZ_CP123994
Organism Bacillus inaquosorum strain M3

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QHF92_RS02610 Protein ID WP_003156187.1
Coordinates 513270..513620 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QHF92_RS02605 Protein ID WP_003225183.1
Coordinates 512984..513265 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHF92_RS02585 (QHF92_02585) 509345..509944 - 600 WP_003240338.1 rhomboid family intramembrane serine protease -
QHF92_RS02590 (QHF92_02590) 510039..510404 + 366 WP_003240339.1 holo-ACP synthase -
QHF92_RS02595 (QHF92_02595) 510569..511585 + 1017 WP_080010740.1 outer membrane lipoprotein carrier protein LolA -
QHF92_RS02600 (QHF92_02600) 511700..512869 + 1170 WP_060397966.1 alanine racemase -
QHF92_RS02605 (QHF92_02605) 512984..513265 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QHF92_RS02610 (QHF92_02610) 513270..513620 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QHF92_RS02615 (QHF92_02615) 513735..514559 + 825 WP_003240350.1 RsbT co-antagonist protein RsbRA -
QHF92_RS02620 (QHF92_02620) 514564..514929 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
QHF92_RS02625 (QHF92_02625) 514933..515334 + 402 WP_003240352.1 serine/threonine-protein kinase RsbT -
QHF92_RS02630 (QHF92_02630) 515346..516353 + 1008 WP_003240354.1 phosphoserine phosphatase RsbU -
QHF92_RS02635 (QHF92_02635) 516415..516744 + 330 WP_003240357.1 anti-sigma factor antagonist RsbV -
QHF92_RS02640 (QHF92_02640) 516741..517223 + 483 WP_003240359.1 anti-sigma B factor RsbW -
QHF92_RS02645 (QHF92_02645) 517189..517977 + 789 WP_003240361.1 RNA polymerase sigma factor SigB -
QHF92_RS02650 (QHF92_02650) 517977..518576 + 600 WP_060397967.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T279313 WP_003156187.1 NZ_CP123994:513270-513620 [Bacillus inaquosorum]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT279313 WP_003225183.1 NZ_CP123994:512984-513265 [Bacillus inaquosorum]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References