Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3089976..3090654 Replicon chromosome
Accession NZ_CP123993
Organism Acinetobacter baumannii strain Ab4294

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QE150_RS15410 Protein ID WP_000009390.1
Coordinates 3089976..3090155 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QE150_RS15415 Protein ID WP_005112025.1
Coordinates 3090241..3090654 (+) Length 138 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE150_RS15390 (QE150_15395) 3085791..3086642 - 852 WP_005112021.1 GPO family capsid scaffolding protein -
QE150_RS15395 (QE150_15400) 3086821..3088599 + 1779 WP_005112022.1 terminase family protein -
QE150_RS15400 (QE150_15405) 3088596..3089642 + 1047 WP_194299481.1 phage portal protein -
QE150_RS15405 (QE150_15410) 3089653..3089868 + 216 WP_227552920.1 hypothetical protein -
QE150_RS15410 (QE150_15415) 3089976..3090155 + 180 WP_000009390.1 type II toxin-antitoxin system HicA family toxin Toxin
QE150_RS15415 (QE150_15420) 3090241..3090654 + 414 WP_005112025.1 hypothetical protein Antitoxin
QE150_RS15420 (QE150_15425) 3090911..3091429 - 519 WP_031945607.1 hypothetical protein -
QE150_RS15445 (QE150_15450) 3092622..3093686 - 1065 WP_001278264.1 quinolinate synthase NadA -
QE150_RS15450 (QE150_15455) 3093833..3095053 - 1221 WP_270901294.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3047961..3090654 42693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 60 a.a.        Molecular weight: 6799.11 Da        Isoelectric Point: 11.1422

>T279312 WP_000009390.1 NZ_CP123993:3089976-3090155 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Download         Length: 180 bp


Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.75 Da        Isoelectric Point: 6.2451

>AT279312 WP_005112025.1 NZ_CP123993:3090241-3090654 [Acinetobacter baumannii]
MKCYVSIHREGEAFIVSSSELPELNSVGYTLEEALSEALDGIETVFEIYMDERKAIPLPSKGKKGEYVVHLPVRVAAKVR
LYNEMISQNVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFQALGKDLDIVIA

Download         Length: 414 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References