Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 11948..12532 Replicon plasmid pAb4294
Accession NZ_CP123992
Organism Acinetobacter baumannii strain Ab4294

Toxin (Protein)


Gene name PumA Uniprot ID N9JY46
Locus tag QE150_RS00055 Protein ID WP_000286963.1
Coordinates 11948..12250 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag QE150_RS00060 Protein ID WP_000985610.1
Coordinates 12251..12532 (+) Length 94 a.a.

Genomic Context

QE150_RS00055QE150_RS00060QE150_RS00065QE150_RS00075QE150_RS00085QE150_RS00090QE150_RS00095QE150_RS00030QE150_RS00035QE150_RS00040QE150_RS00045QE150_RS00050QE150_RS00070QE150_RS00080QE150_RS00100
Location: 11948..12250 (303 bp)
Type: Toxin
Protein ID: WP_000286963.1
Location: 12251..12532 (282 bp)
Type: Antitoxin
Protein ID: WP_000985610.1
Location: 12760..13693 (934 bp)
Type: Others
Protein ID: Protein_12
Location: 14465..14695 (231 bp)
Type: Others
Protein ID: WP_009501150.1
Location: 16109..16465 (357 bp)
Type: Others
Protein ID: WP_000269903.1
Location: 16458..16760 (303 bp)
Type: Others
Protein ID: WP_001140619.1
Location: 16753..16962 (210 bp)
Type: Others
Protein ID: WP_000069471.1
Location: 7173..8776 (1604 bp)
Type: Others
Protein ID: Protein_5
Location: 8846..9181 (336 bp)
Type: Others
Protein ID: WP_004691519.1
Location: 9178..9561 (384 bp)
Type: Others
Protein ID: WP_004762545.1
Location: 10297..11079 (783 bp)
Type: Others
Protein ID: WP_006582115.1
Location: 11365..11748 (384 bp)
Type: Others
Protein ID: WP_281309336.1
Location: 13757..14128 (372 bp)
Type: Others
Protein ID: WP_009501156.1
Location: 14865..15401 (537 bp)
Type: Others
Protein ID: WP_009501148.1
Location: 17087..17299 (213 bp)
Type: Others
Protein ID: WP_016653394.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QE150_RS00030 (QE150_00030)7173..8776-1604Protein_5IS66 family transposase-
QE150_RS00035 (QE150_00035)8846..9181-336WP_004691519.1IS66 family insertion sequence element accessory protein TnpB-
QE150_RS00040 (QE150_00040)9178..9561-384WP_004762545.1transposase-
QE150_RS00045 (QE150_00045)10297..11079-783WP_006582115.1hypothetical protein-
QE150_RS00050 (QE150_00050)11365..11748-384WP_281309336.1hypothetical protein-
QE150_RS00055 (QE150_00055)11948..12250+303WP_000286963.1type II toxin-antitoxin system RelE/ParE family toxinToxin
QE150_RS00060 (QE150_00060)12251..12532+282WP_000985610.1putative addiction module antidote proteinAntitoxin
QE150_RS00065 (QE150_00065)12760..13693+934Protein_12IS5-like element ISAba13 family transposase-
QE150_RS00070 (QE150_00070)13757..14128-372WP_009501156.1RcnB family protein-
QE150_RS00075 (QE150_00075)14465..14695+231WP_009501150.1hypothetical protein-
QE150_RS00080 (QE150_00080)14865..15401-537WP_009501148.1porin family protein-
QE150_RS00085 (QE150_00085)16109..16465+357WP_000269903.1type II toxin-antitoxin system RelE/ParE family toxin-
QE150_RS00090 (QE150_00090)16458..16760+303WP_001140619.1XRE family transcriptional regulator-
QE150_RS00095 (QE150_00095)16753..16962+210WP_000069471.1hypothetical protein-
QE150_RS00100 (QE150_00100)17087..17299-213WP_016653394.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..154924154924
-insideIScluster/Tn--5266..2083015564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11545.02 Da        Isoelectric Point: 4.6838

>T279309 WP_000286963.1 NZ_CP123992:11948-12250 [Acinetobacter baumannii]
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT279309 WP_000985610.1 NZ_CP123992:12251-12532 [Acinetobacter baumannii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A836MGN2

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References