Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 5693513..5694981 Replicon chromosome
Accession NZ_CP123990
Organism Variovorax paradoxus strain MGMM5

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag QHG62_RS27160 Protein ID WP_281148682.1
Coordinates 5693513..5694373 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag QHG62_RS27165 Protein ID WP_281148683.1
Coordinates 5694370..5694981 (-) Length 204 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHG62_RS27130 (QHG62_27130) 5689727..5690779 + 1053 WP_281148674.1 tripartite tricarboxylate transporter substrate binding protein -
QHG62_RS27135 (QHG62_27135) 5690790..5691176 + 387 WP_281148676.1 chorismate mutase family protein -
QHG62_RS27140 (QHG62_27140) 5691305..5691925 + 621 WP_281148677.1 hypothetical protein -
QHG62_RS27145 (QHG62_27145) 5692146..5692547 + 402 WP_281148678.1 hypothetical protein -
QHG62_RS27150 (QHG62_27150) 5692537..5692830 - 294 WP_281148679.1 type II toxin-antitoxin system RelE/ParE family toxin -
QHG62_RS27155 (QHG62_27155) 5692838..5693137 - 300 WP_281148681.1 ribbon-helix-helix protein, CopG family -
QHG62_RS27160 (QHG62_27160) 5693513..5694373 - 861 WP_281148682.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QHG62_RS27165 (QHG62_27165) 5694370..5694981 - 612 WP_281148683.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
QHG62_RS27170 (QHG62_27170) 5695102..5695325 + 224 Protein_5377 helix-turn-helix domain-containing protein -
QHG62_RS27175 (QHG62_27175) 5695227..5695535 - 309 WP_281151845.1 hypothetical protein -
QHG62_RS27180 (QHG62_27180) 5695519..5695776 + 258 WP_281151831.1 plasmid partitioning protein RepB C-terminal domain-containing protein -
QHG62_RS27185 (QHG62_27185) 5695903..5696253 - 351 WP_281148684.1 hypothetical protein -
QHG62_RS27190 (QHG62_27190) 5696278..5696685 - 408 WP_281148685.1 hypothetical protein -
QHG62_RS27195 (QHG62_27195) 5696717..5697019 - 303 WP_281148686.1 hypothetical protein -
QHG62_RS27200 (QHG62_27200) 5697190..5697399 + 210 WP_281148687.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5670873..5718878 48005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-263)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(10-56)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 31539.23 Da        Isoelectric Point: 7.1059

>T279308 WP_281148682.1 NZ_CP123990:c5694373-5693513 [Variovorax paradoxus]
MSGNLAASVRARLKQHADATKQDFNLILTYYGLERLLYRLSISPHATNYLLKGALLFSLWYDHPHRPTRDADLLGFGPDD
TVTAVAAFREVCQIEVEDGVAFDPASVKGSVIRKEAGYGGVRVELQAKLDGARIALQVDIGFGDAVTPAPESVSYPVLLA
DLPAPQLRCYPKYTVIAEKLHAVCLLGMANTRLKDYFDLWVLLADHALETAELRRAVKATFERRKLAFPATIPSGLSDAF
VQDAAKQSQWTAFLKKNRLDALDLAEVVARLRGEFEKLLVSHSTDA

Download         Length: 861 bp

Antitoxin


Download         Length: 204 a.a.        Molecular weight: 22376.07 Da        Isoelectric Point: 10.2990

>AT279308 WP_281148683.1 NZ_CP123990:c5694981-5694370 [Variovorax paradoxus]
MGSDSALEQAVLALAERRPLLRARELAEQGLPTVVLSRLVSAGKLDRVARGVYTLPDRALSEHRSLAEVALRVPRGVVCL
LSALRVHGIGTQAPFEVWIAIPRHSPRPRLDRPALRVVRMSGTALTEGIEPMEIDGVKVPVFNAAKTVADCFKYRNKIGL
DVALEALRDGWSQRKLTIDALWHYATVDRVANVMRPYLESVTA

Download         Length: 612 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References