Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1041506..1042277 Replicon chromosome
Accession NZ_CP123983
Organism Staphylococcus haemolyticus strain SH9361

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag QHG39_RS05355 Protein ID WP_011275410.1
Coordinates 1042128..1042277 (+) Length 50 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q4L7F8
Locus tag QHG39_RS05350 Protein ID WP_011275409.1
Coordinates 1041506..1042105 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHG39_RS05330 (QHG39_05330) 1037389..1038843 + 1455 WP_049426528.1 ABC transporter substrate-binding protein/permease -
QHG39_RS05335 (QHG39_05335) 1038836..1039558 + 723 WP_016931345.1 amino acid ABC transporter ATP-binding protein -
QHG39_RS05340 (QHG39_05340) 1039736..1040863 + 1128 WP_281133008.1 tRNA epoxyqueuosine(34) reductase QueG -
QHG39_RS05345 (QHG39_05345) 1040864..1041334 + 471 WP_049394705.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QHG39_RS05350 (QHG39_05350) 1041506..1042105 + 600 WP_011275409.1 glucosamine-6-phosphate isomerase Antitoxin
QHG39_RS05355 (QHG39_05355) 1042128..1042277 + 150 WP_011275410.1 SAS053 family protein Toxin
QHG39_RS05360 (QHG39_05360) 1042488..1042883 + 396 WP_011275411.1 hypothetical protein -
QHG39_RS05365 (QHG39_05365) 1043090..1044475 + 1386 WP_011275412.1 class II fumarate hydratase -
QHG39_RS05370 (QHG39_05370) 1044541..1045365 - 825 WP_011275413.1 RluA family pseudouridine synthase -
QHG39_RS05375 (QHG39_05375) 1045553..1046662 + 1110 WP_011275414.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5796.18 Da        Isoelectric Point: 3.9484

>T279304 WP_011275410.1 NZ_CP123983:1042128-1042277 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Download         Length: 150 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22272.12 Da        Isoelectric Point: 4.7588

>AT279304 WP_011275409.1 NZ_CP123983:1041506-1042105 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K9C2

References