Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 884863..885395 Replicon chromosome
Accession NZ_CP123983
Organism Staphylococcus haemolyticus strain SH9361

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag QHG39_RS04415 Protein ID WP_011275272.1
Coordinates 885030..885395 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag QHG39_RS04410 Protein ID WP_011275271.1
Coordinates 884863..885033 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHG39_RS04385 (QHG39_04385) 880649..881128 + 480 WP_049394640.1 PH domain-containing protein -
QHG39_RS04390 (QHG39_04390) 881121..882644 + 1524 WP_016931363.1 PH domain-containing protein -
QHG39_RS04395 (QHG39_04395) 882637..883164 + 528 WP_016931364.1 PH domain-containing protein -
QHG39_RS04400 (QHG39_04400) 883174..883533 + 360 WP_037559766.1 holo-ACP synthase -
QHG39_RS04405 (QHG39_04405) 883629..884777 + 1149 WP_016931365.1 alanine racemase -
QHG39_RS04410 (QHG39_04410) 884863..885033 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QHG39_RS04415 (QHG39_04415) 885030..885395 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QHG39_RS04420 (QHG39_04420) 885703..886704 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
QHG39_RS04425 (QHG39_04425) 886803..887129 + 327 WP_011275274.1 anti-sigma factor antagonist -
QHG39_RS04430 (QHG39_04430) 887158..887610 + 453 WP_046309853.1 anti-sigma B factor RsbW -
QHG39_RS04435 (QHG39_04435) 887585..888355 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T279303 WP_011275272.1 NZ_CP123983:885030-885395 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT279303 WP_011275271.1 NZ_CP123983:884863-885033 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References