Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 871938..872449 Replicon chromosome
Accession NZ_CP123983
Organism Staphylococcus haemolyticus strain SH9361

Toxin (Protein)


Gene name TsdT Uniprot ID Q4L7W7
Locus tag QHG39_RS04350 Protein ID WP_011275259.1
Coordinates 872243..872449 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag QHG39_RS04345 Protein ID WP_011275258.1
Coordinates 871938..872231 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHG39_RS04325 (QHG39_04325) 867091..867966 + 876 WP_011275255.1 membrane protein insertase YidC -
QHG39_RS04330 (QHG39_04330) 868161..869477 + 1317 WP_260485096.1 ISL3 family transposase -
QHG39_RS04335 (QHG39_04335) 869526..870167 - 642 WP_016931420.1 HD domain-containing protein -
QHG39_RS04340 (QHG39_04340) 870267..871751 - 1485 WP_016931421.1 cardiolipin synthase -
QHG39_RS04345 (QHG39_04345) 871938..872231 + 294 WP_011275258.1 copper-sensing transcriptional repressor CsoR Antitoxin
QHG39_RS04350 (QHG39_04350) 872243..872449 + 207 WP_011275259.1 heavy-metal-associated domain-containing protein Toxin
QHG39_RS04355 (QHG39_04355) 872557..872694 + 138 WP_011275260.1 Lmo0850 family protein -
QHG39_RS04360 (QHG39_04360) 872719..874387 - 1669 Protein_859 IS1182 family transposase -
QHG39_RS04365 (QHG39_04365) 874643..875842 - 1200 WP_048668183.1 FtsW/RodA/SpoVE family cell cycle protein -
QHG39_RS04370 (QHG39_04370) 876260..877330 + 1071 WP_048668181.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 868161..874387 6226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7857.79 Da        Isoelectric Point: 4.0742

>T279302 WP_011275259.1 NZ_CP123983:872243-872449 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11222.83 Da        Isoelectric Point: 6.6361

>AT279302 WP_011275258.1 NZ_CP123983:871938-872231 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1K7I8

Antitoxin

Source ID Structure

References