279300

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1108495..1109266 Replicon chromosome
Accession NZ_CP123979
Organism Staphylococcus haemolyticus strain SH1275

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag QHG38_RS05575 Protein ID WP_011275410.1
Coordinates 1109117..1109266 (+) Length 50 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q4L7F8
Locus tag QHG38_RS05570 Protein ID WP_011275409.1
Coordinates 1108495..1109094 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHG38_RS05550 (QHG38_05550) 1104378..1105832 + 1455 WP_033079569.1 ABC transporter substrate-binding protein/permease -
QHG38_RS05555 (QHG38_05555) 1105825..1106547 + 723 WP_016931345.1 amino acid ABC transporter ATP-binding protein -
QHG38_RS05560 (QHG38_05560) 1106725..1107852 + 1128 WP_011275407.1 tRNA epoxyqueuosine(34) reductase QueG -
QHG38_RS05565 (QHG38_05565) 1107853..1108323 + 471 WP_016931343.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QHG38_RS05570 (QHG38_05570) 1108495..1109094 + 600 WP_011275409.1 glucosamine-6-phosphate isomerase Antitoxin
QHG38_RS05575 (QHG38_05575) 1109117..1109266 + 150 WP_011275410.1 SAS053 family protein Toxin
QHG38_RS05580 (QHG38_05580) 1109477..1109872 + 396 WP_011275411.1 hypothetical protein -
QHG38_RS05585 (QHG38_05585) 1110079..1111464 + 1386 WP_037571293.1 class II fumarate hydratase -
QHG38_RS05590 (QHG38_05590) 1111530..1112354 - 825 WP_011275413.1 RluA family pseudouridine synthase -
QHG38_RS05595 (QHG38_05595) 1112542..1113651 + 1110 WP_011275414.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5796.18 Da        Isoelectric Point: 3.9484

>T279300 WP_011275410.1 NZ_CP123979:1109117-1109266 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Download         Length: 150 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22272.12 Da        Isoelectric Point: 4.7588

>AT279300 WP_011275409.1 NZ_CP123979:1108495-1109094 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K9C2

References