Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 964398..964930 Replicon chromosome
Accession NZ_CP123979
Organism Staphylococcus haemolyticus strain SH1275

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag QHG38_RS04735 Protein ID WP_011275272.1
Coordinates 964565..964930 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag QHG38_RS04730 Protein ID WP_011275271.1
Coordinates 964398..964568 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHG38_RS04705 (QHG38_04705) 960184..960663 + 480 WP_049394640.1 PH domain-containing protein -
QHG38_RS04710 (QHG38_04710) 960656..962179 + 1524 WP_016931363.1 PH domain-containing protein -
QHG38_RS04715 (QHG38_04715) 962172..962699 + 528 WP_016931364.1 PH domain-containing protein -
QHG38_RS04720 (QHG38_04720) 962709..963068 + 360 WP_037559766.1 holo-ACP synthase -
QHG38_RS04725 (QHG38_04725) 963164..964312 + 1149 WP_240557223.1 alanine racemase -
QHG38_RS04730 (QHG38_04730) 964398..964568 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QHG38_RS04735 (QHG38_04735) 964565..964930 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QHG38_RS04740 (QHG38_04740) 965238..966239 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
QHG38_RS04745 (QHG38_04745) 966338..966664 + 327 WP_011275274.1 anti-sigma factor antagonist -
QHG38_RS04750 (QHG38_04750) 966693..967145 + 453 WP_046309853.1 anti-sigma B factor RsbW -
QHG38_RS04755 (QHG38_04755) 967120..967890 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 958657..959973 1316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T279299 WP_011275272.1 NZ_CP123979:964565-964930 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT279299 WP_011275271.1 NZ_CP123979:964398-964568 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References