Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 949976..950487 Replicon chromosome
Accession NZ_CP123979
Organism Staphylococcus haemolyticus strain SH1275

Toxin (Protein)


Gene name TsdT Uniprot ID Q4L7W7
Locus tag QHG38_RS04665 Protein ID WP_011275259.1
Coordinates 950281..950487 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag QHG38_RS04660 Protein ID WP_011275258.1
Coordinates 949976..950269 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHG38_RS04640 (QHG38_04640) 945129..946004 + 876 WP_011275255.1 membrane protein insertase YidC -
QHG38_RS04645 (QHG38_04645) 946199..947515 + 1317 WP_281136884.1 ISL3 family transposase -
QHG38_RS04650 (QHG38_04650) 947564..948205 - 642 WP_016931420.1 HD domain-containing protein -
QHG38_RS04655 (QHG38_04655) 948305..949789 - 1485 WP_016931421.1 cardiolipin synthase -
QHG38_RS04660 (QHG38_04660) 949976..950269 + 294 WP_011275258.1 copper-sensing transcriptional repressor CsoR Antitoxin
QHG38_RS04665 (QHG38_04665) 950281..950487 + 207 WP_011275259.1 heavy-metal-associated domain-containing protein Toxin
QHG38_RS04670 (QHG38_04670) 950595..950732 + 138 WP_011275260.1 Lmo0850 family protein -
QHG38_RS04675 (QHG38_04675) 950757..952425 - 1669 Protein_922 IS1182 family transposase -
QHG38_RS04680 (QHG38_04680) 952681..953880 - 1200 WP_048668183.1 FtsW/RodA/SpoVE family cell cycle protein -
QHG38_RS04685 (QHG38_04685) 954298..955368 + 1071 WP_048668181.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 946199..952425 6226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7857.79 Da        Isoelectric Point: 4.0742

>T279298 WP_011275259.1 NZ_CP123979:950281-950487 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11222.83 Da        Isoelectric Point: 6.6361

>AT279298 WP_011275258.1 NZ_CP123979:949976-950269 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1K7I8

Antitoxin

Source ID Structure

References