279297

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1327701..1328617 Replicon chromosome
Accession NZ_CP123977
Organism Bacillus subtilis subsp. subtilis strain WH60A

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag QEP20_RS06975 Protein ID WP_003244695.1
Coordinates 1327871..1328617 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag QEP20_RS06970 Protein ID WP_003232646.1
Coordinates 1327701..1327871 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP20_RS06935 (QEP20_06935) 1324567..1324893 + 327 WP_069703538.1 XkdW family protein -
QEP20_RS06940 (QEP20_06940) 1324890..1325054 + 165 WP_014479563.1 XkdX family protein -
QEP20_RS06945 (QEP20_06945) 1325098..1325937 + 840 WP_029727045.1 phage-like element PBSX protein XepA -
QEP20_RS06950 (QEP20_06950) 1325990..1326259 + 270 WP_015252265.1 hemolysin XhlA family protein -
QEP20_RS06955 (QEP20_06955) 1326272..1326535 + 264 WP_014479566.1 phage holin -
QEP20_RS06960 (QEP20_06960) 1326548..1327441 + 894 WP_029727044.1 N-acetylmuramoyl-L-alanine amidase -
QEP20_RS06965 (QEP20_06965) 1327478..1327615 - 138 WP_119899277.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QEP20_RS06970 (QEP20_06970) 1327701..1327871 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
QEP20_RS06975 (QEP20_06975) 1327871..1328617 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QEP20_RS06980 (QEP20_06980) 1328727..1329728 - 1002 WP_003232642.1 inorganic phosphate transporter -
QEP20_RS06985 (QEP20_06985) 1329741..1330358 - 618 WP_003218470.1 DUF47 domain-containing protein -
QEP20_RS06990 (QEP20_06990) 1330634..1331950 - 1317 WP_015252262.1 serine/threonine exchanger -
QEP20_RS06995 (QEP20_06995) 1332339..1333289 + 951 WP_014476561.1 ring-cleaving dioxygenase -
QEP20_RS07000 (QEP20_07000) 1333398..1333493 + 96 Protein_1315 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T279297 WP_003244695.1 NZ_CP123977:c1328617-1327871 [Bacillus subtilis subsp. subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT279297 WP_003232646.1 NZ_CP123977:c1327871-1327701 [Bacillus subtilis subsp. subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References