Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 249989..250601 Replicon chromosome
Accession NZ_CP123969
Organism Streptococcus agalactiae strain CS2108

Toxin (Protein)


Gene name parE Uniprot ID A0A8G2N8L3
Locus tag QGO80_RS01435 Protein ID WP_000384860.1
Coordinates 249989..250324 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag QGO80_RS01440 Protein ID WP_000259017.1
Coordinates 250314..250601 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGO80_RS01410 (QGO80_01410) 245178..245819 + 642 WP_000591144.1 hypothetical protein -
QGO80_RS01415 (QGO80_01415) 246119..246994 + 876 WP_000421240.1 hypothetical protein -
QGO80_RS01420 (QGO80_01420) 247030..247464 + 435 WP_001220479.1 hypothetical protein -
QGO80_RS01425 (QGO80_01425) 247781..249046 + 1266 WP_281137013.1 MobV family relaxase -
QGO80_RS01430 (QGO80_01430) 249214..249684 + 471 WP_000130119.1 hypothetical protein -
QGO80_RS01435 (QGO80_01435) 249989..250324 - 336 WP_000384860.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QGO80_RS01440 (QGO80_01440) 250314..250601 - 288 WP_000259017.1 hypothetical protein Antitoxin
QGO80_RS01445 (QGO80_01445) 251108..251398 + 291 WP_000078283.1 WXG100 family type VII secretion target -
QGO80_RS01450 (QGO80_01450) 251500..251907 + 408 WP_000749954.1 hypothetical protein -
QGO80_RS01455 (QGO80_01455) 251907..252467 + 561 WP_001865562.1 hypothetical protein -
QGO80_RS01460 (QGO80_01460) 252440..253120 + 681 WP_001865565.1 hypothetical protein -
QGO80_RS01465 (QGO80_01465) 253105..253491 + 387 WP_000259069.1 hypothetical protein -
QGO80_RS01470 (QGO80_01470) 253525..253806 + 282 WP_000052406.1 hypothetical protein -
QGO80_RS01475 (QGO80_01475) 254649..255509 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13227.87 Da        Isoelectric Point: 4.5348

>T279292 WP_000384860.1 NZ_CP123969:c250324-249989 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT279292 WP_000259017.1 NZ_CP123969:c250601-250314 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References