Detailed information of TA system TA027929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4700346..4701016
• Replicon: chromosome
• Accession: NC_018025
• Organism: Desulfomonile tiedjei DSM 6799

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: I4CAT5
• Locus tag: DESTI_RS20030
• Protein ID: WP_014811802.1
• Coordinates: 4700588..4701016 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DESTI_RS20025
• Protein ID: WP_041287370.1
• Coordinates: 4700346..4700591 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESTI_RS19995	4695893..4696663	+	771	WP_014811795.1	hypothetical protein	-
DESTI_RS20000	4696664..4697452	+	789	WP_014811796.1	hypothetical protein	-
DESTI_RS20005	4697613..4698137	-	525	WP_014811797.1	class IV adenylate cyclase	-
DESTI_RS20010	4698483..4698713	+	231	WP_014811798.1	TM0996/MTH895 family glutaredoxin-like protein	-
DESTI_RS20015	4699050..4699409	+	360	WP_014811799.1	hypothetical protein	-
DESTI_RS20020	4699997..4700287	+	291	WP_014811800.1	hypothetical protein	-
DESTI_RS20025	4700346..4700591	+	246	WP_041287370.1	hypothetical protein	Antitoxin
DESTI_RS20030	4700588..4701016	+	429	WP_014811802.1	type II toxin-antitoxin system VapC family toxin	Toxin
DESTI_RS20035	4701282..4701575	+	294	WP_014811803.1	nucleotidyltransferase family protein	-
DESTI_RS20040	4701647..4702900	+	1254	WP_014811804.1	SIR2 family protein	-
DESTI_RS20045	4702934..4703557	-	624	WP_014811805.1	NYN domain-containing protein	-
DESTI_RS20050	4704188..4704661	-	474	WP_014811806.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16170.60 Da
• Isoelectric Point: 5.9700

>T27929 WP_014811802.1 NC_018025:4700588-4701016 [Desulfomonile tiedjei DSM 6799]
MILVDANILLYAEDSLHPRHEQARSWWDTQLSGTETVCLCWTVLCAFIRIGTNSRVFETPLSLEQALARVQSWLDQPCTR
IIRPTERHWTILQQMLVEGQAVANLVTDAHLAALAIEHGCELASTDSDFARFTKLKWKNPLI

Nucleotide

• Length: 429 bp

>T27929 NC_018025:4700588-4701016 [Desulfomonile tiedjei DSM 6799]
TTGATTCTCGTCGATGCCAACATTCTTCTGTATGCGGAAGACTCTCTTCACCCTCGTCACGAGCAAGCCCGCTCATGGTG
GGATACCCAGCTATCCGGCACTGAAACTGTATGTCTATGCTGGACGGTTCTCTGCGCATTTATTCGGATAGGAACCAATT
CGAGGGTTTTTGAAACACCTCTTTCTCTCGAACAAGCACTTGCTCGTGTCCAGAGTTGGCTGGACCAGCCATGTACACGC
ATCATTCGTCCAACTGAACGTCACTGGACTATTCTTCAGCAAATGCTAGTGGAAGGTCAGGCCGTTGCCAATTTGGTTAC
AGATGCACATTTAGCTGCTCTTGCCATCGAACATGGCTGCGAGTTGGCCTCCACCGATTCTGATTTTGCACGTTTCACCA
AGCTGAAGTGGAAGAATCCTCTCATCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9247.59 Da
• Isoelectric Point: 10.4384

>AT27929 WP_041287370.1 NC_018025:4700346-4700591 [Desulfomonile tiedjei DSM 6799]
MRTTLSIDDDVIERAKAIAAKLRRPFRAVVNDALRAGLDQMEKPARKRAYRTEPHAMGLRSGRNLDNIQELLAQIEGEDF
R

Nucleotide

• Length: 246 bp

>AT27929 NC_018025:4700346-4700591 [Desulfomonile tiedjei DSM 6799]
ATGAGAACAACATTATCAATAGACGATGACGTGATCGAAAGGGCGAAGGCAATTGCAGCTAAACTCCGCAGGCCATTCAG
AGCGGTTGTAAATGACGCTCTTCGTGCCGGTCTTGACCAAATGGAGAAGCCTGCAAGAAAGCGTGCCTATAGAACGGAAC
CTCACGCCATGGGCCTTCGATCCGGTCGTAATCTGGATAATATTCAAGAATTGTTGGCTCAGATCGAAGGAGAGGACTTC
CGTTGA

Structures

Toxin

• AlphaFold DB: I4CAT5