Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3453904..3454522 Replicon chromosome
Accession NZ_CP123963
Organism Escherichia coli strain L6-21

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QC817_RS17000 Protein ID WP_001291435.1
Coordinates 3454304..3454522 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QC817_RS16995 Protein ID WP_000344800.1
Coordinates 3453904..3454278 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC817_RS16985 (3448993) 3448993..3450186 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QC817_RS16990 (3450209) 3450209..3453358 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QC817_RS16995 (3453904) 3453904..3454278 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QC817_RS17000 (3454304) 3454304..3454522 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QC817_RS17005 (3454694) 3454694..3455245 + 552 WP_000102564.1 maltose O-acetyltransferase -
QC817_RS17010 (3455361) 3455361..3455831 + 471 WP_000136192.1 YlaC family protein -
QC817_RS17015 (3455995) 3455995..3457545 + 1551 WP_072645851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QC817_RS17020 (3457587) 3457587..3457940 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QC817_RS17030 (3458319) 3458319..3458630 + 312 WP_000409911.1 MGMT family protein -
QC817_RS17035 (3458661) 3458661..3459233 - 573 WP_281103610.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279285 WP_001291435.1 NZ_CP123963:3454304-3454522 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279285 WP_000344800.1 NZ_CP123963:3453904-3454278 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References