Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2261081..2261719 Replicon chromosome
Accession NZ_CP123963
Organism Escherichia coli strain L6-21

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QC817_RS11075 Protein ID WP_000813794.1
Coordinates 2261081..2261257 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QC817_RS11080 Protein ID WP_001270286.1
Coordinates 2261303..2261719 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC817_RS11055 (2256700) 2256700..2257875 - 1176 WP_001236265.1 BenE family transporter YdcO -
QC817_RS11060 (2257967) 2257967..2258503 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QC817_RS11065 (2258576) 2258576..2260537 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QC817_RS11070 (2260629) 2260629..2260859 - 231 WP_000494244.1 YncJ family protein -
QC817_RS11075 (2261081) 2261081..2261257 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QC817_RS11080 (2261303) 2261303..2261719 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QC817_RS11085 (2261798) 2261798..2263204 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QC817_RS11090 (2263449) 2263449..2264594 + 1146 WP_000047418.1 ABC transporter substrate-binding protein -
QC817_RS11095 (2264612) 2264612..2265625 + 1014 WP_000220393.1 ABC transporter ATP-binding protein -
QC817_RS11100 (2265626) 2265626..2266567 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T279283 WP_000813794.1 NZ_CP123963:2261081-2261257 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT279283 WP_001270286.1 NZ_CP123963:2261303-2261719 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References