Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 2222280..2222920 | Replicon | chromosome |
| Accession | NZ_CP123958 | ||
| Organism | Mannheimia haemolytica strain 190176 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A378NFX7 |
| Locus tag | QH638_RS11475 | Protein ID | WP_006250075.1 |
| Coordinates | 2222738..2222920 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A378NFW9 |
| Locus tag | QH638_RS11470 | Protein ID | WP_006250074.1 |
| Coordinates | 2222280..2222699 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QH638_RS11450 | 2217793..2218599 | + | 807 | WP_006248821.1 | tryptophan synthase subunit alpha | - |
| QH638_RS11455 | 2218649..2220055 | + | 1407 | WP_006253513.1 | YdgA family protein | - |
| QH638_RS11460 | 2220122..2221162 | - | 1041 | WP_015587023.1 | IS481 family transposase | - |
| QH638_RS11465 | 2221300..2221944 | - | 645 | WP_006253274.1 | tyrosine-type recombinase/integrase | - |
| QH638_RS11470 | 2222280..2222699 | - | 420 | WP_006250074.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| QH638_RS11475 | 2222738..2222920 | - | 183 | WP_006250075.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| QH638_RS11480 | 2223052..2223549 | - | 498 | WP_006250077.1 | hypothetical protein | - |
| QH638_RS11485 | 2223542..2223922 | - | 381 | WP_006248823.1 | hypothetical protein | - |
| QH638_RS11490 | 2223997..2224680 | - | 684 | WP_006248824.1 | S24 family peptidase | - |
| QH638_RS11495 | 2224811..2225011 | + | 201 | WP_006248825.1 | YdaS family helix-turn-helix protein | - |
| QH638_RS11500 | 2225032..2226099 | + | 1068 | WP_006253284.1 | hypothetical protein | - |
| QH638_RS11505 | 2226109..2226267 | + | 159 | WP_006247809.1 | hypothetical protein | - |
| QH638_RS11510 | 2226327..2227367 | - | 1041 | WP_015587043.1 | IS481 family transposase | - |
| QH638_RS11515 | 2227484..2227783 | - | 300 | WP_006247810.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2164697..2288001 | 123304 | |
| - | flank | IS/Tn | - | - | 2220122..2221162 | 1040 | |
| - | flank | IS/Tn | - | - | 2226327..2227367 | 1040 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6933.03 Da Isoelectric Point: 10.3446
>T279267 WP_006250075.1 NZ_CP123958:c2222920-2222738 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
Download Length: 183 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15938.30 Da Isoelectric Point: 4.6963
>AT279267 WP_006250074.1 NZ_CP123958:c2222699-2222280 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQHFTILPH
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQHFTILPH
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NFX7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NFW9 |