Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1842140..1842662 Replicon chromosome
Accession NZ_CP123958
Organism Mannheimia haemolytica strain 190176

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag QH638_RS09390 Protein ID WP_006249269.1
Coordinates 1842140..1842436 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag QH638_RS09395 Protein ID WP_006249270.1
Coordinates 1842420..1842662 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QH638_RS09375 1837195..1838520 + 1326 WP_006249264.1 anti-phage deoxyguanosine triphosphatase -
QH638_RS09380 1838641..1838940 + 300 WP_006249265.1 hypothetical protein -
QH638_RS09385 1839101..1842013 + 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
QH638_RS09390 1842140..1842436 + 297 WP_006249269.1 BrnT family toxin Toxin
QH638_RS09395 1842420..1842662 + 243 WP_006249270.1 CopG family antitoxin Antitoxin
QH638_RS09400 1842674..1843342 + 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QH638_RS09405 1843320..1843895 - 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QH638_RS09410 1843955..1844797 + 843 WP_006249273.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QH638_RS09415 1844920..1845561 + 642 WP_006249274.1 orotate phosphoribosyltransferase -
QH638_RS09420 1845735..1846824 + 1090 Protein_1807 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T279266 WP_006249269.1 NZ_CP123958:1842140-1842436 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT279266 WP_006249270.1 NZ_CP123958:1842420-1842662 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References