Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1550616..1551266 Replicon chromosome
Accession NZ_CP123958
Organism Mannheimia haemolytica strain 190176

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag QH638_RS07880 Protein ID WP_006249411.1
Coordinates 1550877..1551266 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag QH638_RS07875 Protein ID WP_006249412.1
Coordinates 1550616..1550876 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QH638_RS07860 1546304..1549837 + 3534 WP_006253629.1 transcription-repair coupling factor -
QH638_RS07865 1550000..1550287 + 288 WP_006251764.1 BrnT family toxin -
QH638_RS07870 1550288..1550500 + 213 WP_006251765.1 BrnA antitoxin family protein -
QH638_RS07875 1550616..1550876 + 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QH638_RS07880 1550877..1551266 + 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
QH638_RS07885 1551286..1552524 + 1239 WP_006253630.1 peptidase T -
QH638_RS07915 1553267..1554052 + 786 WP_006251768.1 hypothetical protein -
QH638_RS07920 1554126..1554986 + 861 WP_006250124.1 metal ABC transporter permease -
QH638_RS07925 1554979..1555788 + 810 WP_006250123.1 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T279265 WP_006249411.1 NZ_CP123958:1550877-1551266 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT279265 WP_006249412.1 NZ_CP123958:1550616-1550876 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References