Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 217732..218328 Replicon chromosome
Accession NZ_CP123958
Organism Mannheimia haemolytica strain 190176

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QH638_RS01195 Protein ID WP_006249776.1
Coordinates 217732..217956 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A547EKP0
Locus tag QH638_RS01200 Protein ID WP_006249777.1
Coordinates 217999..218328 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QH638_RS01175 213613..214515 - 903 WP_006249771.1 DMT family transporter -
QH638_RS01180 214512..214868 - 357 WP_006249772.1 dihydroneopterin aldolase -
QH638_RS01185 214938..215543 + 606 WP_006249773.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
QH638_RS01190 215617..217524 - 1908 WP_006249774.1 DNA topoisomerase IV subunit B -
QH638_RS01195 217732..217956 + 225 WP_006249776.1 type II toxin-antitoxin system HicA family toxin Toxin
QH638_RS01200 217999..218328 + 330 WP_006249777.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QH638_RS01205 218367..218753 - 387 WP_006249778.1 Cu(I)-responsive transcriptional regulator -
QH638_RS01210 218842..219042 + 201 WP_006249779.1 heavy metal-associated domain-containing protein -
QH638_RS01215 219095..221287 + 2193 WP_006249780.1 copper-translocating P-type ATPase -
QH638_RS01220 221340..222125 - 786 WP_006249781.1 tRNA pseudouridine(38-40) synthase TruA -
QH638_RS01225 222190..222879 - 690 WP_006253589.1 GTP cyclohydrolase I FolE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(28-73)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 10.5597

>T279261 WP_006249776.1 NZ_CP123958:217732-217956 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGR

Download         Length: 225 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12312.06 Da        Isoelectric Point: 4.7022

>AT279261 WP_006249777.1 NZ_CP123958:217999-218328 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A547EKP0

References