Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 217732..218328 Replicon chromosome
Accession NZ_CP123958
Organism Mannheimia haemolytica strain 190176

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QH638_RS01195 Protein ID WP_006249776.1
Coordinates 217732..217956 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A547EKP0
Locus tag QH638_RS01200 Protein ID WP_006249777.1
Coordinates 217999..218328 (+) Length 110 a.a.

Genomic Context


QH638_RS01185QH638_RS01195QH638_RS01200QH638_RS01210QH638_RS01215QH638_RS01175QH638_RS01180QH638_RS01190QH638_RS01205QH638_RS01220QH638_RS01225
Location: 214938..215543 (606 bp)
Type: Others
Protein ID: WP_006249773.1
Location: 217732..217956 (225 bp)
Type: Toxin
Protein ID: WP_006249776.1
Location: 217999..218328 (330 bp)
Type: Antitoxin
Protein ID: WP_006249777.1
Location: 218842..219042 (201 bp)
Type: Others
Protein ID: WP_006249779.1
Location: 219095..221287 (2193 bp)
Type: Others
Protein ID: WP_006249780.1
Location: 213613..214515 (903 bp)
Type: Others
Protein ID: WP_006249771.1
Location: 214512..214868 (357 bp)
Type: Others
Protein ID: WP_006249772.1
Location: 215617..217524 (1908 bp)
Type: Others
Protein ID: WP_006249774.1
Location: 218367..218753 (387 bp)
Type: Others
Protein ID: WP_006249778.1
Location: 221340..222125 (786 bp)
Type: Others
Protein ID: WP_006249781.1
Location: 222190..222879 (690 bp)
Type: Others
Protein ID: WP_006253589.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QH638_RS01175213613..214515-903WP_006249771.1DMT family transporter-
QH638_RS01180214512..214868-357WP_006249772.1dihydroneopterin aldolase-
QH638_RS01185214938..215543+606WP_006249773.1glycerol-3-phosphate 1-O-acyltransferase PlsY-
QH638_RS01190215617..217524-1908WP_006249774.1DNA topoisomerase IV subunit B-
QH638_RS01195217732..217956+225WP_006249776.1type II toxin-antitoxin system HicA family toxinToxin
QH638_RS01200217999..218328+330WP_006249777.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
QH638_RS01205218367..218753-387WP_006249778.1Cu(I)-responsive transcriptional regulator-
QH638_RS01210218842..219042+201WP_006249779.1heavy metal-associated domain-containing protein-
QH638_RS01215219095..221287+2193WP_006249780.1copper-translocating P-type ATPase-
QH638_RS01220221340..222125-786WP_006249781.1tRNA pseudouridine(38-40) synthase TruA-
QH638_RS01225222190..222879-690WP_006253589.1GTP cyclohydrolase I FolE-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(28-73)

Antitoxin

(55-105)


Sequences


Toxin        


Download         Length: 75 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 10.5597

>T279261 WP_006249776.1 NZ_CP123958:217732-217956 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGR

Download         Length: 225 bp


Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12312.06 Da        Isoelectric Point: 4.7022

>AT279261 WP_006249777.1 NZ_CP123958:217999-218328 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV

Download         Length: 330 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A547EKP0

References