279255

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1193403..1194016 Replicon chromosome
Accession NZ_CP123957
Organism Pseudomonas marginalis strain MGMM3

Toxin (Protein)


Gene name hicA Uniprot ID A0A1X7GMT0
Locus tag QGQ83_RS05395 Protein ID WP_027607491.1
Coordinates 1193403..1193654 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1C1W2P5
Locus tag QGQ83_RS05400 Protein ID WP_065939763.1
Coordinates 1193651..1194016 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGQ83_RS05395 (QGQ83_05395) 1193403..1193654 + 252 WP_027607491.1 type II toxin-antitoxin system HicA family toxin Toxin
QGQ83_RS05400 (QGQ83_05400) 1193651..1194016 + 366 WP_065939763.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QGQ83_RS05405 (QGQ83_05405) 1194040..1195212 - 1173 WP_281113477.1 MFS transporter -
QGQ83_RS05410 (QGQ83_05410) 1195253..1196608 - 1356 WP_281113478.1 MATE family efflux transporter -
QGQ83_RS05415 (QGQ83_05415) 1196863..1197951 - 1089 WP_281113479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9509.10 Da        Isoelectric Point: 10.0458

>T279255 WP_027607491.1 NZ_CP123957:1193403-1193654 [Pseudomonas marginalis]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13241.00 Da        Isoelectric Point: 6.6276

>AT279255 WP_065939763.1 NZ_CP123957:1193651-1194016 [Pseudomonas marginalis]
VNNQLKHNGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCQALGQTPEKPCKGSFNVRVGH
DLHLAAALEATRKKVTLNDLTRQALNEFLQHHRGDSCPVTG

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7GMT0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C1W2P5

References