Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 14727..15277 Replicon plasmid pA
Accession NZ_CP123954
Organism Pseudomonas aeruginosa strain 59

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag P4N66_RS35180 Protein ID WP_019727125.1
Coordinates 14727..15002 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6B1YL09
Locus tag P4N66_RS35185 Protein ID WP_019727126.1
Coordinates 15002..15277 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4N66_RS35130 (P4N66_pAgene0011) 9852..10151 + 300 WP_196994194.1 hypothetical protein -
P4N66_RS35135 10264..10470 + 207 WP_152996423.1 hypothetical protein -
P4N66_RS35140 (P4N66_pAgene0012) 10497..10751 + 255 WP_196994195.1 hypothetical protein -
P4N66_RS35145 (P4N66_pAgene0013) 11337..12014 + 678 WP_034018017.1 SOS response-associated peptidase -
P4N66_RS35150 (P4N66_pAgene0014) 12123..12425 + 303 WP_023131919.1 anti-CRISPR protein AcrE1 -
P4N66_RS35155 (P4N66_pAgene0015) 12448..12870 + 423 WP_196994196.1 anti-CRISPR protein AcrF3 -
P4N66_RS35160 (P4N66_pAgene0016) 12883..13122 + 240 WP_196994197.1 anti-CRISPR protein -
P4N66_RS35165 (P4N66_pAgene0017) 13119..13322 + 204 WP_031757130.1 helix-turn-helix transcriptional regulator -
P4N66_RS35170 (P4N66_pAgene0018) 13418..13738 + 321 WP_196994198.1 hypothetical protein -
P4N66_RS35175 (P4N66_pAgene0019) 14220..14636 + 417 WP_196994199.1 hypothetical protein -
P4N66_RS35180 (P4N66_pAgene0020) 14727..15002 - 276 WP_019727125.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4N66_RS35185 (P4N66_pAgene0021) 15002..15277 - 276 WP_019727126.1 ribbon-helix-helix domain-containing protein Antitoxin
P4N66_RS35190 (P4N66_pAgene0022) 15552..15938 + 387 WP_019727127.1 hypothetical protein -
P4N66_RS35195 (P4N66_pAgene0023) 15999..16292 + 294 WP_019727128.1 hypothetical protein -
P4N66_RS35200 (P4N66_pAgene0025) 16616..16924 + 309 WP_019727129.1 TrfB-related DNA-binding protein -
P4N66_RS35205 (P4N66_pAgene0028) 17574..18026 + 453 WP_019727132.1 DNA repair protein RadC -
P4N66_RS35210 (P4N66_pAgene0030) 18464..18712 + 249 WP_058130600.1 hypothetical protein -
P4N66_RS35215 (P4N66_pAgene0031) 18762..19013 - 252 WP_058130599.1 hypothetical protein -
P4N66_RS35220 (P4N66_pAgene0032) 19072..19356 + 285 WP_019727136.1 hypothetical protein -
P4N66_RS35225 (P4N66_pAgene0033) 19399..19776 + 378 WP_019727137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..54339 54339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-48)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10779.36 Da        Isoelectric Point: 7.1659

>T279254 WP_019727125.1 NZ_CP123954:c15002-14727 [Pseudomonas aeruginosa]
MELKWTSKGLSDVARLYEFLATVNREAAARTVQQLTSAPTALLTNPRLGERLEEFEPRDVRRILIGHYEMRYEILDSCIY
VLRLWHTREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10142.32 Da        Isoelectric Point: 4.8433

>AT279254 WP_019727126.1 NZ_CP123954:c15277-15002 [Pseudomonas aeruginosa]
MSTAAKPTRTVTAHVPVDLAERVDAIAERLERSKNWIVRQALSAWIDQEDERSRLTREALDDVDAGRVVDHQAVQAWAES
LGTDSPLPVPR

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1YL09

References