Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 5662221..5663137 Replicon chromosome
Accession NZ_CP123953
Organism Pseudomonas aeruginosa strain 59

Toxin (Protein)


Gene name slvT Uniprot ID A0A212BIN6
Locus tag P4N66_RS27540 Protein ID WP_021018402.1
Coordinates 5662613..5663137 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2I0C738
Locus tag P4N66_RS27535 Protein ID WP_010792483.1
Coordinates 5662221..5662616 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4N66_RS27520 (P4N66_gene5448) 5658244..5658768 - 525 WP_010792479.1 hypothetical protein -
P4N66_RS27525 (P4N66_gene5450) 5659647..5659928 - 282 WP_010792481.1 hypothetical protein -
P4N66_RS27530 (P4N66_gene5451) 5660077..5662011 + 1935 WP_021018401.1 hypothetical protein -
P4N66_RS27535 (P4N66_gene5452) 5662221..5662616 + 396 WP_010792483.1 hypothetical protein Antitoxin
P4N66_RS27540 5662613..5663137 + 525 WP_021018402.1 RES family NAD+ phosphorylase Toxin
P4N66_RS27545 (P4N66_gene5453) 5663183..5664433 - 1251 WP_010792484.1 TerD family protein -
P4N66_RS27550 (P4N66_gene5454) 5664630..5665685 - 1056 WP_021018403.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
P4N66_RS27555 (P4N66_gene5455) 5666063..5666254 + 192 WP_010792486.1 hypothetical protein -
P4N66_RS27560 (P4N66_gene5457) 5666676..5667821 - 1146 WP_021018404.1 glycerate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19011.47 Da        Isoelectric Point: 4.4540

>T279252 WP_021018402.1 NZ_CP123953:5662613-5663137 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14810.93 Da        Isoelectric Point: 7.2048

>AT279252 WP_010792483.1 NZ_CP123953:5662221-5662616 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A212BIN6

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0C738

References